Application of Calculated Panel Reactive Antibody Using HLA Frequencies in Koreans
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چکیده
منابع مشابه
Application of Calculated Panel Reactive Antibody Using HLA Frequencies in Koreans
BACKGROUND Introduction of the Luminex panel reactive antibody (PRA)-single antigen (SA) assay has increased the detection rates of unacceptable antigens in sensitized patients; the calculated PRA (CPRA) level represents the percentage of actual organ donors that express 1 or more of these unacceptable antigens. We developed a CPRA calculator based on the HLA frequencies in Koreans to measure s...
متن کامل[New HLA nomenclature (2010) and its clinical application in Koreans].
Human leukocyte antigen (HLA) gene region encodes a set of HLA molecules functioning critical roles in immune response. Each HLA gene locus shows extensive polymorphism with ever-increasing number of alleles. The HLA nomenclature system for alleles defined by DNA typing was first established in 1987 and has been revised several times. Recently, it has been revised again with a new frame that ca...
متن کاملOvine panel reactive antibody assay of HLA responsivity to allograft bioengineered vascular scaffolds.
BACKGROUND Increasing evidence implicates immune response as a contributing factor in the failure of allograft valve transplants. Increases in panel reactive antibodies have been identified in human subjects. To correlate these responses with novel preimplantation processing methods to reduce cellularity, both a relevant panel reactive antibody assay and a chronic implantation animal model are ...
متن کاملHLA and Disease Associations in Koreans
The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and d...
متن کاملAssessment of Spanish Panel Reactive Antibody Calculator and Potential Usefulness
BACKGROUND AND OBJECTIVES The calculated panel reactive of antibodies (cPRAs) necessary for kidney donor-pair exchange and highly sensitized programs are estimated using different panel reactive antibody (PRA) calculators based on big enough samples in Eurotransplant (EUTR), United Network for Organ Sharing (UNOS), and Canadian Transplant Registry (CTR) websites. However, those calculators can ...
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ژورنال
عنوان ژورنال: Annals of Laboratory Medicine
سال: 2012
ISSN: 2234-3806,2234-3814
DOI: 10.3343/alm.2012.32.1.66